1:00 Alpha-Synuclein Biomarkers: Overcoming Biological Complexity to Transform Parkinson’s & Synucleinopathy Research
Time: 1:00 pm
day: Pre-Conference Workshop Day
Details:
Exploring the evolving role of alpha-synuclein in Parkinson’s and related disorders, focusing on both its promise and its limitations. Delve into the challenges of using alpha-synuclein for patient stratification and monitoring in clinical trials, review cutting-edge blood-based and seed amplification assay technologies that aim to reduce reliance on imaging, and unpack the complex biology of protein aggregates.
In this session:
- Examine the role of alpha-synuclein in Parkinson’s and related synucleinopathies, and explore the key challenges limiting its use in clinical trial stratification and disease monitoring
- Evaluate emerging seed amplification assays and blood-based detection methods aiming to reduce reliance on invasive CSF collection or expensive imaging techniques for diagnosis and staging
- Discuss the biological complexity of protein aggregates and whether understanding their behaviour can provide insight beyond mere disease correlation – single particle proteomics
